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    Sustained-release verapamil: multiple-dose pharmacokinetic ... - NCBI Sustained-release verapamil: multiple-dose pharmacokinetic ... - NCBI
    J Cardiovasc Pharmacol. 1989;13 Suppl 4:S57-9. Sustained-release verapamil: multiple-dose pharmacokinetic comparison of 120-mg and 240-mg tablets and ...

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    Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. The following side effects have been reported by at least 1 of people taking this medication. Plasma samples were collected for 24 h after dosing on day 8 of each phase and assayed for verapamil and norverapamil by high-performance liquid chromatography.

    Speak to your doctor about how any drug interactions are being managed or should be managed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

    Ten healthy male volunteers, aged 18-37 years, entered a balanced crossover comparison of the pharmacokinetic profiles of (a) one 240 mg verapamil hcl sustained-release tablet (isoptin sr 240, securon sr) (1 x 240 mg) and (b) either two half 240-mg verapamil hcl sustained-release tablets (2 x half 240-mg tablets, study 1) or two 120-mg verapamil hcl sustained-release tablets (isoptin sr 120) (2 x 120 mg, study 2). Each phase of the two studies consisted of once-daily administration of verapamil for 8 days with a 1-week washout period between phases. It can be harmful for people to take this medication if their doctor has not prescribed it.

    For most conditions, the dose of verapamil for adults is 80 mg to 120 mg taken 3 or 4 times daily with food. A side effect is an unwanted response to a medication when it is taken in normal doses. Do not give this medication to anyone else, even if they have the same symptoms as you do.

    If you are a breast-feeding mother and are taking verapamil, it may affect your baby. This medication may be available under multiple brand names andor in several different forms. Low blood pressure symptoms of tiredness and weakness with faintness have been reported following single doses and even after some months of treatment with verapamil.

    If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have a neuromuscular disease such as myasthenia gravis, lambert-eaton syndrome, or duchennes muscular dystrophy, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Verapamil works partially by reducing the force of the hearts contractions which can cause the symptoms of heart failure to become worse.


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    If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Low blood pressure symptoms of tiredness and weakness with faintness have been reported following single doses and even after some months of treatment with verapamil. Each phase of the two studies consisted of once-daily administration of verapamil for 8 days with a 1-week washout period between phases. Report an abnormally low heart rate (less than 50 beats per minute) or persistent fatigue to your doctor.

    Each yellow, biconvex, film-coated tablet marked vl breakline 80 on one side and g on the other contains 80 mg of verapamil hydrochloride. This medication may be available under multiple brand names andor in several different forms. The mean bioavailability of the 120-mg tablet relative to the 240-mg tablet was 107, with 95 confidence limits of 81 and 142, indicating that the amount of verapamil available from the two tablets was similar. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.

    For most conditions, the dose of verapamil for adults is 80 mg to 120 mg taken 3 or 4 times daily with food. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. The safety and effectiveness of using this medication have not been established for children. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. Doses over 240 mg daily of the sr tablets should be taken in 2 divided doses (morning and evening) with food. This medication should not be used during pregnancy unless the benefits outweigh the risks. Check with your doctor as soon as possible if any of the following side effects occur signs of a serious allergic reaction (e. The sustained release (sr) form of this medication is used for the treatment of when beta-blockers or diuretics (water pills) are not recommended or have caused unacceptable side effects. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. When treating specific conditions where the heart muscle is enlarged and preventing the heart from working efficiently, the dose may be increased to 600 mg or 720 mg of verapamil divided throughout the day.

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